The homeobox protein Prox1 is a negative modulator of ERRa/PGC-1a bioenergetic functions
نویسندگان
چکیده
Goodman Cancer Centre, McGill University, Montréal, Québec H3A 1A3, Canada; Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada; Department of Systems Biology, Massachusetts General Hospital, Cambridge, Massachusetts 02142, USA; Centre for Human Genetic Research, Massachusetts General Hospital, Cambridge, Massachusetts 02142, USA; Broad Institute of Massachusetts Institute of Technology/Harvard, Cambridge, Massachusetts 02142, USA; Department of Medicine, McGill University, Montréal, Québec H3G 1Y6, Canada; Department of Oncology, McGill University, Montréal, Québec H3G 1Y6, Canada
منابع مشابه
The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions.
Estrogen-related receptor alpha (ERRalpha) and proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) play central roles in the transcriptional control of energy homeostasis, but little is known about factors regulating their activity. Here we identified the homeobox protein prospero-related homeobox 1 (Prox1) as one such factor. Prox1 interacts with ERRalpha and PGC-1alpha, occu...
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Homeobox genes are a family of transcription factors that play a pivotal role in embryogenesis. Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor gene or oncogene in various types of cancer, including oral squamous cell carcinoma (OSCC). We have previously identified PROX1 as a downregulated gene in OSCC. The aim of this study is to clarify the underlying mechanism by...
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